ColabFold
Steinegger Lab (Seoul National University)
Wraps AlphaFold2 with MMseqs2-based MSA generation, making AF2 runs 40-60x faster. Accessible via Google Colab or local install.
Best For
High-throughput structure prediction without large compute infrastructure
License
Open Source (MIT)
Strengths
- +40-60x faster than standard AF2
- +Free via Google Colab
- +No GPU setup required
Limitations
- −Inherits all AF2 limitations
- −MSA quality depends on MMseqs2 server
- −No ligand co-folding
R&D Pipeline Coverage
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