BindCraft

Diffusion-based generative model for de novo protein backbone design. Generates novel protein structures conditioned on binding targets, symmetry, or functional sites.

Inverse folding model: generates amino acid sequences predicted to fold into a target 3D backbone structure. Standard component of all modern protein design pipelines.

Diffusion-based generative model that jointly designs antibody CDR sequences and 3D structures conditioned on antigen structure.

RFdiffusion fine-tuned for de novo antibody design. Generates VHHs, scFvs, and full antibodies targeting user-specified epitopes. Experimentally validated with cryo-EM.

Antibody-specific inverse folding model fine-tuned from ESM-IF1. Designs sequences predicted to maintain structural fold given an antibody backbone.