biotech.today
All Modalities
TherapeuticsGrowing

Oligonucleotides (ASO, siRNA, miRNA)

Short nucleic acid sequences that modulate gene expression at the RNA level. Antisense oligonucleotides (ASOs), small interfering RNA (siRNA), and microRNA therapeutics can silence or modulate previously undruggable targets.

Key Companies

AlnylamIonis PharmaceuticalsArrowhead PharmaceuticalsSilence Therapeutics

Recent Signals

CLINICAL SIGNAL

Alnylam's Cardiovascular siRNA Program Hits Phase 3 Primary Endpoint

The RNA interference pioneer reports positive topline data for its Lp(a)-targeting siRNA in cardiovascular disease, validating oligonucleotide approaches beyond rare disease and into large patient populations.

Apr 5, 2026 · 5 min read