Details
- ●Modalities: CAR-T cell therapy, next-gen cell therapies
- ●Therapeutic areas: oncology, hematology
- ●Key targets: BCMA, CD20, DLL3, claudin-18.2, GPC3
- ●Indications: multiple myeloma, diffuse large B-cell lymphoma, small cell lung cancer, gastric cancer
- ●Funding: N/A (public since 2020, Carvykti generating ~$1B+ annual revenue)
Partners & investors
Public (NASDAQ: LEGN)· Investor
Johnson & Johnson (commercialization partner)· Investor
GenScript (parent company)· Investor
Key considerations
- ●AI tools in use: Proprietary CAR construct design platform, Automated cell manufacturing systems
- ●Dual-epitope CAR design for enhanced binding (computational protein engineering)
- ●Manufacturing automation to reduce vein-to-vein time
- ●Global manufacturing expansion (US, Belgium, China)
Pipeline
- Preclinical1
- Phase 12
- Approved1
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